Piperacillin Tazobactam (Incitazim 4.5gm)

This combination medication is an antibacterial agent, prescribed for various infections such as Nosocomial pneumonia. It blocks the bacteria’s cell wall growth, which kills the bacteria. Tazobactam inhibits the action of bacterial beta-lactamases. It is added to the extended-spectrum beta-lactam antibiotic piperacillin. It broadens the spectrum of piperacillin by making it effective against organisms that express beta-lactamase and would normally degrade piperacillin.

• Caution should be exercised in patients with a history of asthma; hay fever; or kidney, liver, or gastrointestinal disease (especially colitis), during pregnancy and breastfeeding.

• Repeated electrolyte estimations may be needed especially in patients with low potassium levels.

• Monitor blood functions regularly.

Common side effects may include:

• diarrhea, constipation;
• nausea
• headache
• sleep problems (insomnia)
• Bladder pain
•  bloating or swelling of the face, arms, hands, lower legs, or feet
• blurred vision
• burning upper abdominal or stomach pain
• changes in urination
• chest pain
• confusion
• dizziness  faintness,
• lightheadedness when getting up suddenly from a lying or sitting position
• fever or sweating
• headache
• lower back or side pain
• nausea
• pain, tenderness, or swelling of the foot or leg
• pain, warmth, or burning in the fingers, toes, and legs
• problems with vision or hearing
• skin rash
• slow or fast heartbeat
• troubled breathing

• cold sweats
• cough
• deep or fast breathing with dizziness
• diarrhea, watery and severe, which may also be bloody

• drowsiness

What should I avoid while using piperacillin and tazobactam?

Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, call your doctor before using anti-diarrhea medicine.

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