Haloperidol Decanoate 50mg Injection (Haloper-La)

Haloperidol Decanoate 50mg Injection (Haloper-La)

Therapeutic action

• Long-acting antipsychotic.

Forms and strengths, route of administration

• 50 mg in 1 ml ampoule (50 mg/ml) for IM injection.
  DO NOT ADMINISTER BY IV INJECTION.

Dosage and duration

• Adult: one injection every 3 to 4 weeks

The initial dose of haloperidol decanoate corresponds to approximately 10 times the daily dose of oral haloperidol.

Contra-indications, adverse effects, precautions

• Do not administer to patients with cardiac disorders (cardiac fail
• ure, recent myocardial infarction, conduction disorders, bradycardia, etc.), dementia (e.g. Alzheimer’s disease), Parkinson’s disease, and a history of the neuroleptic malignant syndrome.
• Administer with caution and carefully monitor use in elderly patients with hypokalaemia, hypotension, hyperthyroidism, renal or hepatic impairment, and a history of seizures.
• It may cause drowsiness, extrapyramidal syndrome, early or tardive dyskinesia, constipation, dry mouth, sexual dysfunction, QT-prolongation, ventricular arrhythmia, and orthostatic hypotension.
• In the event of extrapyramidal symptoms, combine with biperiden or trihexyphenidyl.
• Avoid or monitor combination with:
• fluoxetine, paroxetine, sertraline, promethazine, ritonavir (increased plasma concentrations of haloperidol);
• carbamazepine, rifampicin, phenobarbital, phenytoin (decreased plasma concentrations of haloperidol);
• drugs that prolong the QT interval (amiodarone, chloroquine, erythromycin, fluconazole, mefloquine, pentamidine, quinine, etc.).
• Avoid alcohol during treatment.
• Avoid women of childbearing age or offer effective contraception.
• Pregnancy and breast-feeding: avoid.

Indications

• Chronic psychosis, maintenance therapy after stabilization with oral haloperidol.

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