Voriconazole Injection (Worizole-200)

VORICONAZOLE SIDE EFFECTS

• Most common side effects of Voriconazole Injection include peripheral edema, headaches, trouble breathing, diarrhea, vomiting, abdominal pain, nausea, rashes, fever,  anxiety, insomnia, confusion, weakness, tingling, sleepiness, dizziness, irregular heartbeats, slow or fast heartbeats, low blood pressure, stomach upset, constipation, jaundice, hair loss, flaky skin, itchiness, red skin, back pain, chest pain, and chills.
• Some adverse effects may also appear in patients with this drug which are squamous cell skin cancer, damage due to phototoxicity, and Stevens-Johnson syndrome; in long-term use, there is a warning of the risk of bone fluorosis and periostitis.

WARNINGS AND PRECAUTIONS

• It is toxic to the fetus; pregnant women should not take it and women taking it should not become pregnant. Use during pregnancy may result in harm to the baby.
• People who have hereditary intolerance for galactose, Lapp lactase deficiency, or glucose-galactose malabsorption should not take this drug.
• It should be used with caution in people with arrhythmias or long QT.
• In long-term use, there is a warning of the risk of bone fluorosis and periostitis.
• Vernier should not be used in conjunction with many drugs including sirolimus, rifampicin, rifabutin, carbamazepine, quinidine, and ergot alkaloids).
• Intravenous use of Voriconazole 200mg must be avoided in patients with severe as well as moderate renal impairment unless an assessment of the risk/benefit to the patient clarifies the use of intravenous voriconazole.
• People with this medication should avoid night driving, because VFEND may cause vision problems like blurry vision.
• Also need to avoid driving or using dangerous machinery, if you have any change in your eyesight.
• No dose adjustment is needed for renal impairment or advanced age, but children seem to clear voriconazole faster than adults and drug levels may need monitoring.

SUPPLIED/STORAGE AND HANDLING

DRUG INTERACTIONS OF VORICONAZOLEBeing metabolized by hepatic cytochrome P450, voriconazole interacts with many drugs. Voriconazole should not be used in conjunction with many drugs which are as:

• sirolimus
• rifampicin
• rifabutin
• carbamazepine (quinidine and ergot alkaloids)

And also the dose adjustments or monitoring when coadministered with others such as warfarin, fluconazole, tacrolimus, ciclosporin, omeprazole, and phenytoin.

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